Marlene S. Orandle

Assistant Professor, Viral Pathogenesis

Phone: 225-578-9597
Fax: 225-578-9701
morandle@vetmed.lsu.edu

Education:
B.A. St. Mary's College of Maryland • D.V.M. Iowa State University • Ph.D. University of Florida

NIH Postdoctoral Fellow 1999-2001, New England Regional Primate Research Center
NIH Postdoctoral Fellow 2001-03, Tulane Regional Primate Research Center

Dr. Orandle joined the faculty within the Department of Pathobiological Sciences at the School of Veterinary Medicine in 2004. After receiving a Ph.D. at the University of Florida, College of Veterinary Medicine in 1999, Dr. Orandle completed NIH Postdoctoral Fellowships at the New England and Tulane National Primate Research Centers where she studied the pathogenesis of simian immunodeficiency virus (SIV) infection as a model for AIDS.

Research Interests
Dr. Orandle's primary research interest is in the study of comparative lentiviral pathogenesis with a specific focus on host factors contributing to the development of neurological disease. Ongoing research in her laboratory is focused on understanding the mechanisms involved in trafficking of SIV-infected cells across the blood-brain barrier in rhesus macaques. Dr. Orandle maintains close collaborations with investigators at the Tulane National Primate Research Center in Covington, LA, where the animal-related component of her research is conducted.

Selected Publications
Orandle MS, Papadi GP, Bubenik LJ, Dailey CI, Johnson CM. Selective thymocyte depletion and immunoglobulin coating in the thymus of cats infected with feline immunodeficiency virus. AIDS Res Hum Retroviruses 1997;13:611-619

Johnson CM, Papadi GP, Tompkins WA, Sellon RK, Orandle MS, Bellah JR, Bubenik LJ. Biphasic thymus response by kittens inoculated with feline immunodeficiency virus during fetal development. Vet Pathol 1998;35:191-201

Bortnick SJ, Orandle MS, Papadi GP, Johnson CM. Lymphocyte subsets in the neonatal and juvenile cat: comparison of blood and lymphoid tissues. Laboratory Animal Science 1999;49:395-400.

Orandle MS, Crawford PC, Levy JK, Udoji R, Papadi GP, Ciccarone T, Mergia A, Johnson CJ. CD8+ thymic lymphocytes express reduced levels of CD8-beta and increased interferon gamma in cats perinatally infected with the JSY3 molecular clone of feline immunodeficiency virus. AIDS Res and Hum Retroviruses 16:15 2000; 1559-1571.

Orandle, M. S., K. C. Williams, A. G. MacLean, S. V. Westmoreland, and A. A. Lackner. 2001. Macaques with rapid disease progression and simian immunodeficiency virus encephalitis have a unique cytokine profile in peripheral lymphoid tissues. J Virol. 75:4448-52.

MacLean, A. G., M. S. Orandle, X. Alvarez, K. C. Williams, and A. A. Lackner. 2001. Rhesus macaque brain microvessel endothelial cells behave in a manner phenotypically distinct from umbilical vein endothelial cells. J Neuroimmunol. 118:223-32.

Williams, K., A. Schwartz, S. Corey, M. Orandle, W. Kennedy, B. Thompson, X. Alvarez, C. Brown, S. Gartner, and A. Lackner. 2002. Proliferating Cellular Nuclear Antigen Expression as a Marker of Perivascular Macrophages in Simian Immunodeficiency Virus Encephalitis. Am J Pathol. 161:575-585.

Orandle, M. S., A. G. MacLean, V. G. Sasseville, X. Alvarez, and A. A. Lackner. 2002. Enhanced expression of proinflammatory cytokines in the central nervous system is associated with neuroinvasion by simian immunodeficiency virus and the development of encephalitis. J Virol. 76:57974.

MacLean, A.G., George, K., Williams, K.C., MacKey, J., Alvarex, X., Aye, P., Orandle, M.S., Lackner, A.A. 2002. Characterization of an in vitro rhesus macaque blood- brain barrier. J. Neuroimmunol, 2002